MIAO Xiao-hui, SHI Zi-yan, CHEN Hong-xi, et al.Anxiety and Depression in Patients with Neuromyelitis Optica.Journal of Sichuan University (Medical Science Edition),2017;48(6):900-904
Anxiety and Depression in Patients with Neuromyelitis Optica
ObjectiveTo assess anxiety and depression in patients with neuromyelitis optica (NMO). MethodsEligible patients with NMO were assessed with Hamilton anxiety rating scale-14 (HARS-14), Hamilton depression rating scale-21 (HDRS-21) and expanded disability status scale (EDSS). ResultsA total of 65 NMO patients 〔(39.85±10.36) yr.，male/female: 5/60) participated in this study. They had a median EDSS score of 2.5 and a mean score of (37.37±20.44) for bodily pain. About 76.9% of patients were NMO-IgG seropositive. The participants had (11.03±6.95) HARS-14 scores and (11.74±7.78) HDRS-21 scores, with 27.69% (18/65) being diagnosed with anxiety and 24.62% (16/65) being depressed. The EDSS scores were correlated with HARS-14 scores (r=0.285, P=0.004) and HDRS-21 scores (r=0.328, P=0.008). Bodily pain was negatively correlated with HARS-14 scores (r=-0.561, P<0.001) and HDRS-21 scores (r=-0.496, P<0.001). Relapse was correlated with anxiety (r=0.285, P=0.022). Age, sex, duration of disease, and serum NMO-IgG were not correlated with HARS-14 scores and HDRS-21 scores. The logistic regression model identified bodily pain as a predictor of anxiety and depression in NMO patients (OR=1.052, 1.046, respectively, P<0.05). ConclusionDisability and bodily pain are associated with anxiety and depression in NMO patients, while relapse is associated with anxiety only. Bodily pain is a predictor of anxiety and depression in NMO patients.
