苗晓慧, 石紫燕, 陈虹西, 等.视神经脊髓炎患者焦虑抑郁与临床特点相关性研究.四川大学学报(医学版),2017,48(6):900-904
视神经脊髓炎患者焦虑抑郁与临床特点相关性研究
Anxiety and Depression in Patients with Neuromyelitis Optica
  
中文关键词:  视神经脊髓炎焦虑抑郁躯体疼痛
英文关键词:Neuromyelitis opticaAnxietyDepressionBodily pain
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中文摘要:
      目的 研究视神经脊髓炎(NMO)患者焦虑、抑郁现状及其与临床特点的相关性。方法 对符合标准的NMO患者使用汉密尔顿焦虑量表-14(HARS-14)、汉密尔顿抑郁量表-21(HDRS-21)和扩展残疾状况量表(EDSS)进行评分,并分析焦虑、抑郁障碍与临床特点的关系。结果 65例NMO患者(5例男性,60例女性),平均年龄(39.85±10.36)岁,EDSS评分中位数为2.5分,躯体疼痛平均得分为(37.37±20.44)分,血清NMO-IgG阳性比例76.9%。焦虑评分结果平均值为(11.03±6.95)分,抑郁评分结果平均值为(11.74±7.78)分。65例患者中,有焦虑患者占27.69%(18/65),有抑郁患者占24.62(16/65)。单因素分析显示,EDSS评分与焦虑评分(r=0.285, P=0.004)、抑郁评分(r=0.328, P=0.008)呈低度正相关,躯体疼痛与焦虑评分(r=- 0.561, P<0.001)、抑郁评分(r=- 0.496, P< 0.001)呈中度负相关,复发次数与焦虑评分(r=0.285, P=0.022)呈低度正相关。年龄、性别、病程、NMO-IgG对患者焦虑、抑郁均无影响。Logistic回归分析显示,躯体疼痛是NMO患者焦虑、抑郁的主要危险因素(比值比分别为1.052、1.046, P<0.05)。结论 NMO患者残疾状态与焦虑、抑郁均相关,发作次数与焦虑相关,躯体疼痛是NMO患者焦虑、抑郁的主要危险因素。
英文摘要:
      ObjectiveTo assess anxiety and depression in patients with neuromyelitis optica (NMO). MethodsEligible patients with NMO were assessed with Hamilton anxiety rating scale-14 (HARS-14), Hamilton depression rating scale-21 (HDRS-21) and expanded disability status scale (EDSS). ResultsA total of 65 NMO patients 〔(39.85±10.36) yr.,male/female: 5/60) participated in this study. They had a median EDSS score of 2.5 and a mean score of (37.37±20.44) for bodily pain. About 76.9% of patients were NMO-IgG seropositive. The participants had (11.03±6.95) HARS-14 scores and (11.74±7.78) HDRS-21 scores, with 27.69% (18/65) being diagnosed with anxiety and 24.62% (16/65) being depressed. The EDSS scores were correlated with HARS-14 scores (r=0.285, P=0.004) and HDRS-21 scores (r=0.328, P=0.008). Bodily pain was negatively correlated with HARS-14 scores (r=-0.561, P<0.001) and HDRS-21 scores (r=-0.496, P<0.001). Relapse was correlated with anxiety (r=0.285, P=0.022). Age, sex, duration of disease, and serum NMO-IgG were not correlated with HARS-14 scores and HDRS-21 scores. The logistic regression model identified bodily pain as a predictor of anxiety and depression in NMO patients (OR=1.052, 1.046, respectively, P<0.05). ConclusionDisability and bodily pain are associated with anxiety and depression in NMO patients, while relapse is associated with anxiety only. Bodily pain is a predictor of anxiety and depression in NMO patients.
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