Objective?To prepare and optimize the conditions of Sodium Aescinat micro-emulsion for injection. Methods?Sodium Aescinat O/W micro-emulsion (soybean phospholipids+HS15/glycerin/medium chain triglycerides/water) was formulated guided by the pseudo-titration ternary phase diagram. Results?Stable Sodium Aescinat micro-emulsion was obtained with medium chain triglycerides as oil, soybean phospholipids+HS15 (1∶2) as emulsifier, glycerin as co-emulsifier, and a ratio of emulsifier and co-emulsifier (Km) between 2.00-3.75. Conclusion?Stable Sodium Aescinat micro-emulsion can be prepared with conditions described in this study.
